Exome sequencing is a capture based method developed to identify variants in the coding region of genes which affect protein function. While exome capture methods using PCR, hybrid capture and molecular inversion probes exist, the most common and efficient strategies are in-solution capture methods. In-solution capture utilizes pools of oligonucleotides or probes bound to magnetic beads, whose sequence has been designed to hybridize to exon regions. After binding to genomic DNA, these probes are pulled down and washed, allowing exon regions to be selectively sequenced.
While there are approximately 180,000 exons in the human genome, constituting less than 2% of total sequence, the exome contains ~80-90% of known disease causing variants making it a cost-effective alternative to whole genome sequencing. When performing exome-seq, users should not only consider average on-target coverage but also the local coverage of particular sites of interest. When choosing between exome and whole genome sequencing (WGS), consider that exome sequencing has the advantage that oligonucleotides are designed to particular genomic regions where typical coverage with WGS is not enough for SNP calling. It is also more affordable enabling the analysis of more individuals and populations. With WGS, you can detect variants in regions not covered by exome capture allowing or the identification of structural and non-coding variants associated with disease.
Whole Exome Sequencing Market aims to provide a comprehensive presentation of the global market for Whole Exome Sequencing, with both quantitative and qualitative analysis, to help readers develop business/growth strategies, assess the market competitive situation, analyze their position in the current marketplace, and make informed business decisions regarding Whole Exome Sequencing. Whole Exome Sequencing Market contains market size and forecasts of Whole Exome Sequencing in global, including the following market information:
- Global Whole Exome Sequencing Market Revenue, 2018-2023, 2024-2029, ($ millions)
Global top five companies in 2022 (%)
The global Whole Exome Sequencing market was valued at US$ 304.6 million in 2022 and is projected to reach US$ 628.7 million by 2029, at a CAGR of 10.9% during the forecast period. The influence of COVID-19 and the Russia-Ukraine War were considered while estimating market sizes.
The major players in global Whole Exome Sequencing market include Illumina, Thermofisher, Roche, etc. The top 3 players occupy about 45% shares of the global market. North America and Europe are main markets, they occupy about 70% of the global market. Illumina TruSeq Exome and Roche Nimblegen SeqCap are main types, with a share about 55%. Mendelian Disease and Rare Syndrome Gene Discovery are the main application, which hold a share about 40%.
We surveyed the Whole Exome Sequencing companies, and industry experts on this industry, involving the revenue, demand, product type, recent developments and plans, industry trends, drivers, challenges, obstacles, and potential risks.
Total Market by Segment:
Global Whole Exome Sequencing Market, by Type, 2018-2023, 2024-2029 ($ millions)
Global Whole Exome Sequencing Market Segment Percentages, by Type, 2022 (%)
Agilent HaloPlex
- Agilent SureSelect
- Agilent SureSelect QXT
- Illumina TruSeq Exome
- Roche Nimblegen SeqCap
- MYcroarray MYbaits
Global Whole Exome Sequencing Market, by Application, 2018-2023, 2024-2029 ($ millions)
Global Whole Exome Sequencing Market Segment Percentages, by Application, 2022 (%)
- Correlation Research of Normal Human
- Mendelian Disease and Rare Syndrome Gene Discovery
- The Research of Complex Diseases
- Mouse Exome Sequencing
Global Whole Exome Sequencing Market, By Region and Country, 2018-2023, 2024-2029 ($ Millions)
Global Whole Exome Sequencing Market Segment Percentages, By Region and Country, 2022 (%)
- North America
- US
- Canada
- Mexico
- Europe
- Germany
- France
- U.K.
- Italy
- Russia
- Nordic Countries
- Benelux
- Rest of Europe
- Asia
- China
- Japan
- South Korea
- Southeast Asia
- India
- Rest of Asia
- South America
- Brazil
- Argentina
- Rest of South America
- Middle East & Africa
- Turkey
- Israel
- Saudi Arabia
- UAE
Rest of Middle East & Africa
Competitor Analysis
The report also provides analysis of leading market participants including:
- Key companies Whole Exome Sequencing revenues in global market, 2018-2023 (estimated), ($ millions)
- Key companies Whole Exome Sequencing revenues share in global market, 2022 (%)
- Further, the report presents profiles of competitors in the market, key players include:
- Illumina
- Thermo Fisher
- Roche
- Angilent
- Eurofins
- Sengenics
- Ambry
- Macrogen
- BGI
- Novo Gene
- Outline of Major Chapters:
- Chapter 1: Introduces the definition of Whole Exome Sequencing, market overview.
- Chapter 2: Global Whole Exome Sequencing market size in revenue.
- Chapter 3: Detailed analysis of Whole Exome Sequencing company competitive landscape, revenue and market share, latest development plan, merger, and acquisition information, etc.
- Chapter 4: Provides the analysis of various market segments by type, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.
- Chapter 5: Provides the analysis of various market segments by application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
- Chapter 6: Sales of Whole Exome Sequencing in regional level and country level. It provides a quantitative analysis of the market size and development potential of each region and its main countries and introduces the market development, future development prospects, market space of each country in the world.
- Chapter 7: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including product sales, revenue, price, gross margin, product introduction, recent development, etc.
- Chapter 8: The main points and conclusions of the report.
Industry Market Size
