Global Pharmaceutical Excipients for Non-injection Market 2025: Market Dynamics and Future Outlook to 2032

December 29, 2024
3
Life Sciences

Pharmaceutical excipients play a crucial role in the development of safe, effective, and stable drug formulations. These inactive ingredients, which are combined with active pharmaceutical ingredients (APIs) in medications, enhance the drug’s bioavailability, stability, and efficacy. The pharmaceutical excipients market for non-injection formulations—such as tablets, capsules, and oral liquids—has witnessed significant growth in recent years, driven by advancements in drug delivery systems, increasing healthcare demands, and the growing prevalence of chronic diseases worldwide.

As the pharmaceutical industry evolves, the excipients market is adapting to meet these emerging needs. In this blog, we will explore the key drivers of growth in the pharmaceutical excipients market, provide in-depth analysis, real-time examples, and share accurate statistics to offer a comprehensive understanding of the landscape.

Overview of the Pharmaceutical Excipients Market for Non-Injection Formulations

Pharmaceutical excipients for non-injection formulations are essential to the design of oral dosage forms, such as tablets, capsules, syrups, and powders. These excipients perform a variety of functions including:

Binders: Help in the cohesion of drug particles into tablets or granules.
Fillers (Diluents): Increase the bulk of formulations, especially in tablet and capsule forms.
Disintegrants: Assist in the breakdown of tablets in the digestive tract for faster drug release.
Stabilizers: Enhance the shelf life and prevent the degradation of drugs.
Lubricants: Prevent friction during the manufacturing process.

In 2024, the global pharmaceutical excipients market was valued at USD 4682 million and is expected to grow at a Compound Annual Growth Rate (CAGR) of 9.70%, reaching an estimated value of USD 9819.39 million by 2032. This growth is indicative of the increasing demand for innovative drug delivery systems, the expansion of chronic disease treatments, and advancements in drug formulations.

Key Market Drivers

Several factors are fueling the expansion of the pharmaceutical excipients market, particularly for non-injection drugs:

Increasing Prevalence of Chronic Diseases

The rise in chronic diseases such as diabetes, hypertension, cardiovascular conditions, and obesity has spurred demand for oral medications, which require advanced excipients for effective drug formulation. The World Health Organization (WHO) reports that chronic diseases account for 71% of global deaths, contributing significantly to the demand for non-injection treatments.

Growing Geriatric Population

The global aging population is another major driver of the market. Older adults are more likely to suffer from chronic diseases, thus increasing the need for effective, easy-to-consume drug formulations. The demand for non-injection drug formulations, including tablets and capsules, is expected to rise in response to this demographic shift.

Technological Advancements in Drug Formulations

Ongoing advancements in drug formulation techniques, such as controlled-release, extended-release, and targeted drug delivery systems, have made excipients essential for enhancing drug bioavailability and ensuring therapeutic efficacy. New excipients, such as those used in nanoparticles, are now being developed to address the challenges posed by poorly water-soluble drugs.

Rising Demand for Generic Drugs

As the patent protection for blockbuster drugs expires, there has been a surge in the availability of generic drugs. These drugs require the same quality excipients as branded medications, driving demand for high-quality, cost-effective excipients in the non-injection formulation market.

Market Segmentation

The pharmaceutical excipients market for non-injection formulations is segmented based on product type, functionality, and region.

By Product Type

Binders: Bind the active ingredient and other excipients together to form tablets and granules. The demand for binders is significant in the formulation of solid oral dosages.
Fillers: Filler excipients are the largest segment, especially in tablet and capsule production, where they make up a significant portion of the final product.
Disintegrants: Crucial in oral formulations, disintegrants allow tablets to break apart once ingested, facilitating faster absorption of the API.

By Functionality

The functionality of excipients in non-injection formulations is varied and includes:

Stabilizing excipients: Enhance the chemical stability of the API.
Bioavailability enhancers: Improve the solubility and absorption of poorly soluble APIs.
Lubricants: Improve the flow properties during tablet or capsule production, reducing friction during the manufacturing process.

By Region

North America: Dominates the pharmaceutical excipients market, accounting for over 39% of the total market share in 2024. The region's strong pharmaceutical manufacturing base and high healthcare expenditure contribute significantly to this dominance.
Europe: Holds approximately 30% of the market share, driven by advancements in biopharmaceuticals and significant investment in drug development.
Asia Pacific: Growing rapidly, this region is expected to continue expanding, fueled by the rising adoption of generic drugs, improved healthcare infrastructure, and an aging population.

Download Free Sample Copy >>> "Pharmaceutical Excipients for Non-injection Market"

Real-Time Examples and Case Studies

Taste-Masking Excipients for Pediatric Drugs

Many pediatric medications have a bitter taste that affects patient compliance. Pharmaceutical manufacturers use excipients such as cyclodextrins and sweeteners to mask unpleasant tastes. For example, the pharmaceutical company Pfizer has successfully developed taste-masked oral formulations for its pediatric drugs, helping improve adherence among younger patients.

Solubility Enhancement in Poorly Water-Soluble Drugs

Drugs with poor solubility pose a significant challenge to bioavailability. Excipients such as surfactants (e.g., polysorbates) and solid dispersion techniques have been developed to overcome this issue. The drug Glivec (imatinib), a tyrosine kinase inhibitor, has been formulated with such excipients to enhance solubility, ensuring better absorption and efficacy in cancer treatments.

Sustained-Release Excipients

Sustained-release excipients like hydroxypropyl methylcellulose (HPMC) are commonly used in formulations requiring a controlled release of the drug over time. This excipient is particularly valuable in the development of long-acting drugs for chronic conditions like hypertension and diabetes.

Market Outlook and Future Trends

The pharmaceutical excipients market for non-injection formulations is poised for continued growth. Several trends are shaping the future of the market:

Increased Focus on Personalized Medicine
As the healthcare industry shifts towards personalized medicine, the demand for excipients that can support individualized drug delivery systems will increase. Custom excipients that cater to specific patient needs, such as those with allergies or intolerances, will see heightened demand.
Rise of Biopharmaceuticals
The increasing focus on biologics and biosimilars will require specialized excipients to stabilize and deliver these complex drugs in non-injection forms. With the market for biologics expected to reach USD 700 billion by 2025, excipients tailored for biopharmaceutical formulations will become a key growth area.
Regulatory Changes and Sustainability
As regulatory agencies worldwide push for more sustainable and eco-friendly manufacturing practices, the pharmaceutical excipients market is seeing a shift towards natural and biodegradable excipients. Companies are investing in sustainable sourcing and production methods to meet these requirements.